Nature Communications (Jul 2020)

Predicting and affecting response to cancer therapy based on pathway-level biomarkers

  • Rotem Ben-Hamo,
  • Adi Jacob Berger,
  • Nancy Gavert,
  • Mendy Miller,
  • Guy Pines,
  • Roni Oren,
  • Eli Pikarsky,
  • Cyril H. Benes,
  • Tzahi Neuman,
  • Yaara Zwang,
  • Sol Efroni,
  • Gad Getz,
  • Ravid Straussman

DOI
https://doi.org/10.1038/s41467-020-17090-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Predicting an individual's response to therapy is an important goal for precision medicine. Here, the authors use an algorithm that takes into account the interaction type and directionality of signalling pathways in protein–protein interactions and find that their pathway analysis can predict essential genes, which may be a target for therapy.