Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts
Anna Gasiorek,
Ewelina Dobosz,
Barbara Potempa,
Izabela Ciaston,
Mateusz Wilamowski,
Zuzanna Oruba,
Richard J. Lamont,
Jolanta Jura,
Jan Potempa,
Joanna Koziel
Affiliations
Anna Gasiorek
Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Ewelina Dobosz
Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Barbara Potempa
Department of Oral Immunity and Infectious Diseases, University of Louisville School of Dentistry, University of Louisville, Louisville, Kentucky, USA
Izabela Ciaston
Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Mateusz Wilamowski
Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Zuzanna Oruba
Chair of Periodontology and Clinical Oral Pathology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
Periodontitis is a highly prevalent disease caused by accumulation of a bacterial biofilm. Periodontal pathogens use a number of virulence strategies that are under intensive study to find optimal therapeutic approaches against bone loss.
