Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel

Xiaolong Gao; Philipp A. M. Schmidpeter; Vladimir Berka; Ryan J. Durham; Chen Fan; Vasanthi Jayaraman; Crina M. Nimigean

doi:10.1038/s41467-022-34673-z

Nature Communications (Nov 2022)

Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel

Xiaolong Gao,
Philipp A. M. Schmidpeter,
Vladimir Berka,
Ryan J. Durham,
Chen Fan,
Vasanthi Jayaraman,
Crina M. Nimigean

Affiliations

Xiaolong Gao: Department of Anesthesiology, Weill Cornell Medical College
Philipp A. M. Schmidpeter: Department of Anesthesiology, Weill Cornell Medical College
Vladimir Berka: Department of Biochemistry and Molecular Biology, University of Texas Health Science Center
Ryan J. Durham: Department of Biochemistry and Molecular Biology, University of Texas Health Science Center
Chen Fan: Department of Anesthesiology, Weill Cornell Medical College
Vasanthi Jayaraman: Department of Biochemistry and Molecular Biology, University of Texas Health Science Center
Crina M. Nimigean: Department of Anesthesiology, Weill Cornell Medical College

DOI: https://doi.org/10.1038/s41467-022-34673-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Visualizing conformational changes during ion channel gating is crucial to understand their regulation. Here, Gao et al. capture multiple gating intermediates in a CNG channel as well as subtle, lateral voltage sensor movements necessary for channel opening.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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