Nature Communications (Feb 2020)

Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation

  • Yicheng Wang,
  • Yusuke Maeda,
  • Yi-Shi Liu,
  • Yoko Takada,
  • Akinori Ninomiya,
  • Tetsuya Hirata,
  • Morihisa Fujita,
  • Yoshiko Murakami,
  • Taroh Kinoshita

DOI
https://doi.org/10.1038/s41467-020-14678-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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Glycosylphosphatidylinositol (GPI) anchors are found on many cell surface proteins but their biosynthesis is not fully understood. Here, the authors identify genes involved in GPI galactosylation and reveal functional connections between GPI processing, glycosphingolipid biosynthesis and ER-associated degradation.