Brain and Behavior (Jan 2022)
Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups
- Ashley N. Clausen,
- Kelene A. Fercho,
- Molly Monsour,
- Seth Disner,
- Lauren Salminen,
- Courtney C. Haswell,
- Emily Clarke Rubright,
- Amanda A. Watts,
- M. Nicole Buckley,
- Adi Maron‐Katz,
- Anika Sierk,
- Antje Manthey,
- Benjamin Suarez‐Jimenez,
- Bunmi O. Olatunji,
- Christopher L. Averill,
- David Hofmann,
- Dick J. Veltman,
- Elizabeth A. Olson,
- Gen Li,
- Gina L. Forster,
- Henrik Walter,
- Jacklynn Fitzgerald,
- Jean Théberge,
- Jeffrey S. Simons,
- Jessica A. Bomyea,
- Jessie L. Frijling,
- John H. Krystal,
- Justin T. Baker,
- K. Luan Phan,
- Kerry Ressler,
- Laura K. M. Han,
- Laura Nawijn,
- Lauren A. M. Lebois,
- Lianne Schmaal,
- Maria Densmore,
- Martha E. Shenton,
- Mirjam vanZuiden,
- Murray Stein,
- Negar Fani,
- Raluca M. Simons,
- Richard W. J. Neufeld,
- Ruth Lanius,
- Sanne vanRooij,
- Saskia B.J. Koch,
- Serena Bonomo,
- Tanja Jovanovic,
- Terri deRoon‐Cassini,
- Timothy D. Ely,
- Vincent A. Magnotta,
- Xiaofu He,
- Chadi G. Abdallah,
- Amit Etkin,
- Christian Schmahl,
- Christine Larson,
- Isabelle M. Rosso,
- Jennifer Urbano Blackford,
- Jennifer S. Stevens,
- Judith K. Daniels,
- Julia Herzog,
- Milissa L. Kaufman,
- Miranda Olff,
- Richard J. Davidson,
- Scott R. Sponheim,
- Sven C. Mueller,
- Thomas Straube,
- Xi Zhu,
- Yuval Neria,
- Lee A. Baugh,
- James H. Cole,
- Paul M. Thompson,
- Rajendra A. Morey
Affiliations
- Ashley N. Clausen
- VA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA
- Kelene A. Fercho
- Center for Brain and Behavior Research University of South Dakota Vermillion South Dakota USA
- Molly Monsour
- Duke University Brain Imaging and Analysis Center Durham North Carolina USA
- Seth Disner
- Department of Psychiatry University of Minnesota Medical School Minneapolis Minnesota USA
- Lauren Salminen
- Imaging Genetics Center Mark & Mary Stevens Neuroimaging & Informatics Institute Keck School of Medicine University of Southern California Marina del Rey California USA
- Courtney C. Haswell
- VA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA
- Emily Clarke Rubright
- VA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA
- Amanda A. Watts
- VA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA
- M. Nicole Buckley
- VA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA
- Adi Maron‐Katz
- Department of Psychiatry and Behavioral Sciences Stanford University of Medicine Stanford California USA
- Anika Sierk
- University Medical Centre Charite Berlin Germany
- Antje Manthey
- University Medical Centre Charite Berlin Germany
- Benjamin Suarez‐Jimenez
- Columbia University Medical Center Manhattan New York USA
- Bunmi O. Olatunji
- Department of Psychology Vanderbilt University Nashville Tennessee USA
- Christopher L. Averill
- Clinical Neuroscience Division National Center for PTSD West Haven Connecticut USA
- David Hofmann
- Institute of Medical Psychology and Systems Neuroscience University of Muenster Muenster Germany
- Dick J. Veltman
- Department of Psychiatry Amsterdam University Medical Centers Location VU University Medical Center VU University Amsterdam The Netherlands
- Elizabeth A. Olson
- Harvard Medical School Boston Massachusetts USA
- Gen Li
- Department of Psychology University of Chinese Academy of Sciences Beijing China
- Gina L. Forster
- Brain Health Research Centre Department of Anatomy University of Otago Dunedin New Zealand
- Henrik Walter
- University Medical Centre Charite Berlin Germany
- Jacklynn Fitzgerald
- Marquette University Milwaukee Wisconsin USA
- Jean Théberge
- Department of Medical Biophysics University of Western Ontario London Ontario Canada
- Jeffrey S. Simons
- Center for Brain and Behavior Research University of South Dakota Vermillion South Dakota USA
- Jessica A. Bomyea
- UC San Diego Department of Psychiatry San Deigo California USA
- Jessie L. Frijling
- Department of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The Netherlands
- John H. Krystal
- Clinical Neuroscience Division National Center for PTSD West Haven Connecticut USA
- Justin T. Baker
- Institute for Technology in Psychiatry McLean Hospital Harvard University Belmont Massachusetts USA
- K. Luan Phan
- Department of Psychiatry and Behavioral Health The Ohio State University Columbus Ohio USA
- Kerry Ressler
- Department of Psychiatry Harvard Medical School Boston Massachusetts USA
- Laura K. M. Han
- Department of Psychiatry Amsterdam University Medical Centers VU University Medical Center GGZ inGeest Amsterdam Neuroscience Amsterdam The Netherlands
- Laura Nawijn
- Department of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The Netherlands
- Lauren A. M. Lebois
- Department of Psychiatry Harvard Medical School Boston Massachusetts USA
- Lianne Schmaal
- Centre for Youth Mental Health The University of Melbourne Melbourne Australia
- Maria Densmore
- Department of Psychiatry Western University London Ontario Canada
- Martha E. Shenton
- Department of Psychiatry VA Boston Healthcare System Brockton Massachusetts USA
- Mirjam vanZuiden
- Department of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The Netherlands
- Murray Stein
- UC San Diego Department of Family Medicine and Public Health San Deigo California USA
- Negar Fani
- Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA
- Raluca M. Simons
- Center for Brain and Behavior Research University of South Dakota Vermillion South Dakota USA
- Richard W. J. Neufeld
- Department of Neuroscience Western University London Ontario Canada
- Ruth Lanius
- Department of Neuroscience Western University London Ontario Canada
- Sanne vanRooij
- Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA
- Saskia B.J. Koch
- Department of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The Netherlands
- Serena Bonomo
- New York State Psychiatric Institute New York New York USA
- Tanja Jovanovic
- Department of Psychiatry and Behavioral Neurosciences Wayne State University Detroit Michigan USA
- Terri deRoon‐Cassini
- Medical College of Wisconsin Milwaukee Wisconsin USA
- Timothy D. Ely
- Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA
- Vincent A. Magnotta
- Departments of Radiology Psychiatry and Biomedical Engineering University of Iowa Iowa City Iowa USA
- Xiaofu He
- Columbia University Medical Center Manhattan New York USA
- Chadi G. Abdallah
- Clinical Neuroscience Division National Center for PTSD West Haven Connecticut USA
- Amit Etkin
- Department of Psychiatry and Behavioral Sciences Stanford University of Medicine Stanford California USA
- Christian Schmahl
- Department of Psychosomatic Medicine and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim/Heidelberg University Mannheim Germany
- Christine Larson
- University of Wisconsin‐Milwaukee Milwaukee Wisconsin USA
- Isabelle M. Rosso
- Harvard Medical School Boston Massachusetts USA
- Jennifer Urbano Blackford
- Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center Nashville Tennessee USA
- Jennifer S. Stevens
- Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA
- Judith K. Daniels
- University of Groningen The Netherlands
- Julia Herzog
- Department of Psychosomatic Medicine and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim/Heidelberg University Mannheim Germany
- Milissa L. Kaufman
- Division of Women's Mental Health McLean Hospital Belmont Massachusetts USA
- Miranda Olff
- ARQ National Psychotrauma Centrum Diemen The Netherlands
- Richard J. Davidson
- Center for Healthy Minds Departments of Psychology and Psychiatry University of Wisconsin‐Madison Madison Wisconsin USA
- Scott R. Sponheim
- Department of Psychiatry University of Minnesota Medical School Minneapolis Minnesota USA
- Sven C. Mueller
- Department of Experimental Clinical and Health Psychology Ghent University Ghent Belgium
- Thomas Straube
- Institute of Medical Psychology and Systems Neuroscience University of Muenster Muenster Germany
- Xi Zhu
- Columbia University Medical Center Manhattan New York USA
- Yuval Neria
- Columbia University Medical Center Manhattan New York USA
- Lee A. Baugh
- Center for Brain and Behavior Research University of South Dakota Vermillion South Dakota USA
- James H. Cole
- Centre for Medical Image Computing Computer Science University College London London UK
- Paul M. Thompson
- Imaging Genetics Center Mark & Mary Stevens Neuroimaging & Informatics Institute Keck School of Medicine University of Southern California Marina del Rey California USA
- Rajendra A. Morey
- VA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA
- DOI
- https://doi.org/10.1002/brb3.2413
- Journal volume & issue
-
Vol. 12,
no. 1
pp. n/a – n/a
Abstract
Abstract Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects (N = 2229; 56.2% male) aged 18–69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA‐PGC PTSD sites underwent T1‐weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel‐wise (brainageR) and region‐of‐interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age − chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three‐way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age‐related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan.
Keywords
