Frontiers in Medicine (Jan 2025)

Severe late onset capillary leak syndrome post allo-HSCT successfully treated by bevacizumab: a case report

  • Song Xue,
  • Jiaqi Chen,
  • Yuzhu Shi,
  • Lina Zhang,
  • Man Chen,
  • Huipeng Sun,
  • Xingyu Cao,
  • Fang Wu

DOI
https://doi.org/10.3389/fmed.2024.1483064
Journal volume & issue
Vol. 11

Abstract

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This article describes a case of successful management of late-onset CLS occurring after allo-HSCT, employing bevacizumab as the therapeutic agent. Capillary leak syndrome (CLS) represents a critical complication arising from allogeneic hematopoietic stem cell transplantation (allo-HSCT). The prognosis for CLS remains considerably constrained. A targeted therapeutic approach targeting vascular endothelial growth factor (VEGF) offers a novel strategy for the management of CLS.

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