Nature Communications (Jul 2022)

Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

  • Carys A. Croft,
  • Anna Thaller,
  • Solenne Marie,
  • Jean-Marc Doisne,
  • Laura Surace,
  • Rui Yang,
  • Anne Puel,
  • Jacinta Bustamante,
  • Jean-Laurent Casanova,
  • James P. Di Santo

DOI
https://doi.org/10.1038/s41467-022-32089-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors. Authors here show how the Notch signalling pathway orchestrates ILC development from circulating human ILC precursors via RORC and its target IL-23R.