Strategies for Articular Cartilage Repair and Regeneration

Yanxi Liu; Karan M. Shah; Jian Luo; Jian Luo

doi:10.3389/fbioe.2021.770655

Frontiers in Bioengineering and Biotechnology (Dec 2021)

Strategies for Articular Cartilage Repair and Regeneration

Yanxi Liu,
Karan M. Shah,
Jian Luo,
Jian Luo

Affiliations

Yanxi Liu: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
Karan M. Shah: Department of Oncology and Metabolism, The Medical School, The University of Sheffield, Sheffield, United Kingdom
Jian Luo: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
Jian Luo: Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Centre), Tongji University School of Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fbioe.2021.770655
Journal volume & issue: Vol. 9

Abstract

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Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis. Currently, clinical treatments have limited ability to repair, for they often result in the formation of mechanically inferior cartilage. In this review, we discuss the factors that affect cartilage homeostasis and function, and describe the emerging regenerative approaches that are informing the future treatment options.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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Abstract

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