Analysis of Gastric Juice in Acid Peptic Diseases

Abstract

Background: Peptic ulcer disease is an imbalance between offensive and defensive gastric factors. A bacterium called Helicobacter pylori has been considered a major causative agent for gastric and duodenal ulcers. This is a major cause of mortality in developing countries. Aims and Objectives:The aim of this study was to assess the biochemical parameters in gastric juice of acid peptic disease patients (Study Group) and normal healthy individuals (Control Group) in humans. Material and Methods: A total of 70 patients suffering peptic ulcer disease with H. pylori infection and 15 non-infected individuals were chosen as control group. Results: We observed an increased significant level (p<0.05) in pH, b-glucuronidase activity, malondialdehyde (MDA) and superoxide dismutase (SOD) as well as catalase(CAT) levels in gastric juice and decrease significant level (p<0.05) in pepsin activity, urea, mucin and nitric oxide level. Conclusion: The present study showed variations in levels of MDA, b-glucuronidase, SOD, CAT activities, pepsin, mucin urea and nitric oxide. Therefore these parameters can be used as additional parameters for diagnosis and prognosis of acid peptic diseases. These can be used by clinicians to adopt treatment strategies in betterment of acid peptic disease patients.

Keywords

• Catalase
• b-glucuronidase
• Helicobacter pylori
• Pepsin
• Mucin
• Urea
• Nitric oxide
• Malondialdehyde
• Superoxide dismutase