mSphere
(Apr 2021)
Clustering and Erratic Movement Patterns of Syringe-Injected versus Mosquito-Inoculated Malaria Sporozoites Underlie Decreased Infectivity
C. M. de Korne,
B. M. F. Winkel,
M. N. van Oosterom,
S. Chevalley-Maurel,
H. M. Houwing,
J. C. Sijtsma,
S. Azargoshasb,
E. Baalbergen,
B. M. D. Franke-Fayard,
F. W. B. van Leeuwen,
M. Roestenberg
Affiliations
C. M. de Korne
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
B. M. F. Winkel
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
M. N. van Oosterom
Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
S. Chevalley-Maurel
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
H. M. Houwing
Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
J. C. Sijtsma
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
S. Azargoshasb
Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
E. Baalbergen
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
B. M. D. Franke-Fayard
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
F. W. B. van Leeuwen
Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
M. Roestenberg
ORCiD Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
DOI
https://doi.org/10.1128/mSphere.00218-21
Journal volume & issue
Vol. 6,
no. 2
Abstract
Read online
Malaria still causes a major burden on global health and the economy. The efficacy of live, attenuated malaria sporozoites as vaccine candidates critically depends on their ability to migrate to and infect the host liver.
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