Clustering and Erratic Movement Patterns of Syringe-Injected versus Mosquito-Inoculated Malaria Sporozoites Underlie Decreased Infectivity

C. M. de Korne; B. M. F. Winkel; M. N. van Oosterom; S. Chevalley-Maurel; H. M. Houwing; J. C. Sijtsma; S. Azargoshasb; E. Baalbergen; B. M. D. Franke-Fayard; F. W. B. van Leeuwen; M. Roestenberg

doi:10.1128/mSphere.00218-21

mSphere (Apr 2021)

Clustering and Erratic Movement Patterns of Syringe-Injected versus Mosquito-Inoculated Malaria Sporozoites Underlie Decreased Infectivity

C. M. de Korne,
B. M. F. Winkel,
M. N. van Oosterom,
S. Chevalley-Maurel,
H. M. Houwing,
J. C. Sijtsma,
S. Azargoshasb,
E. Baalbergen,
B. M. D. Franke-Fayard,
F. W. B. van Leeuwen,
M. Roestenberg

Affiliations

C. M. de Korne: Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
B. M. F. Winkel: Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
M. N. van Oosterom: Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
S. Chevalley-Maurel: Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
H. M. Houwing: Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
J. C. Sijtsma: Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
S. Azargoshasb: Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
E. Baalbergen: Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
B. M. D. Franke-Fayard: Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
F. W. B. van Leeuwen: Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
M. Roestenberg: ORCiD; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands

DOI: https://doi.org/10.1128/mSphere.00218-21
Journal volume & issue: Vol. 6, no. 2

Abstract

Read online

Malaria still causes a major burden on global health and the economy. The efficacy of live, attenuated malaria sporozoites as vaccine candidates critically depends on their ability to migrate to and infect the host liver.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

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