Changes in the extracellular matrix of the clitoris caused by aging: a stereological and comparative study

Abstract

Introduction The clitoris is partially responsible for sexual arousal. The integrity of the extracellular matrix is essential for clitoral erection. Sexual dysfunction is a phenomenon associated with age. Material and methods The clitoris of cadavers of 20- to 80-year-old women was excised and histologically processed. Stereological analysis was performed to quantify the volumetric density of collagen, elastic fibers, and smooth muscle. Results A significant increase in collagen and a decrease in smooth muscle and elastic fibers were observed in older women. Conclusions In short, these changes caused by aging could contribute to female sexual dysfunction concerning clitoral orgasm.

Keywords

• clitoris
• aging
• extracellular matrix
• stereology