Nature Communications (Sep 2018)
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
- Molly Went,
- Amit Sud,
- Asta Försti,
- Britt-Marie Halvarsson,
- Niels Weinhold,
- Scott Kimber,
- Mark van Duin,
- Gudmar Thorleifsson,
- Amy Holroyd,
- David C. Johnson,
- Ni Li,
- Giulia Orlando,
- Philip J. Law,
- Mina Ali,
- Bowang Chen,
- Jonathan S. Mitchell,
- Daniel F. Gudbjartsson,
- Rowan Kuiper,
- Owen W. Stephens,
- Uta Bertsch,
- Peter Broderick,
- Chiara Campo,
- Obul R Bandapalli,
- Hermann Einsele,
- Walter A. Gregory,
- Urban Gullberg,
- Jens Hillengass,
- Per Hoffmann,
- Graham H. Jackson,
- Karl-Heinz Jöckel,
- Ellinor Johnsson,
- Sigurður Y. Kristinsson,
- Ulf-Henrik Mellqvist,
- Hareth Nahi,
- Douglas Easton,
- Paul Pharoah,
- Alison Dunning,
- Julian Peto,
- Federico Canzian,
- Anthony Swerdlow,
- Rosalind A. Eeles,
- ZSofia Kote-Jarai,
- Kenneth Muir,
- Nora Pashayan,
- Jolanta Nickel,
- Markus M. Nöthen,
- Thorunn Rafnar,
- Fiona M. Ross,
- Miguel Inacio da Silva Filho,
- Hauke Thomsen,
- Ingemar Turesson,
- Annette Vangsted,
- Niels Frost Andersen,
- Anders Waage,
- Brian A. Walker,
- Anna-Karin Wihlborg,
- Annemiek Broyl,
- Faith E. Davies,
- Unnur Thorsteinsdottir,
- Christian Langer,
- Markus Hansson,
- Hartmut Goldschmidt,
- Martin Kaiser,
- Pieter Sonneveld,
- Kari Stefansson,
- Gareth J. Morgan,
- Kari Hemminki,
- Björn Nilsson,
- Richard S. Houlston,
- The PRACTICAL consortium
Affiliations
- Molly Went
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Amit Sud
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Asta Försti
- German Cancer Research Center
- Britt-Marie Halvarsson
- Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund University
- Niels Weinhold
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Scott Kimber
- Division of Molecular Pathology, The Institute of Cancer Research
- Mark van Duin
- Department of Hematology, Erasmus MC Cancer Institute
- Gudmar Thorleifsson
- deCODE Genetics
- Amy Holroyd
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- David C. Johnson
- Division of Molecular Pathology, The Institute of Cancer Research
- Ni Li
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Giulia Orlando
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Philip J. Law
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Mina Ali
- Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund University
- Bowang Chen
- German Cancer Research Center
- Jonathan S. Mitchell
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Daniel F. Gudbjartsson
- deCODE Genetics
- Rowan Kuiper
- Department of Hematology, Erasmus MC Cancer Institute
- Owen W. Stephens
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Uta Bertsch
- German Cancer Research Center
- Peter Broderick
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Chiara Campo
- German Cancer Research Center
- Obul R Bandapalli
- German Cancer Research Center
- Hermann Einsele
- University Clinic of Würzburg
- Walter A. Gregory
- Clinical Trials Research Unit, University of Leeds
- Urban Gullberg
- Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund University
- Jens Hillengass
- Department of Internal Medicine V, University of Heidelberg
- Per Hoffmann
- Institute of Human Genetics, University of Bonn
- Graham H. Jackson
- Royal Victoria Infirmary
- Karl-Heinz Jöckel
- Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg–Essen
- Ellinor Johnsson
- Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund University
- Sigurður Y. Kristinsson
- Department of Hematology, Landspitali, National University Hospital of Iceland
- Ulf-Henrik Mellqvist
- Section of Hematology, Sahlgrenska University Hospital
- Hareth Nahi
- Center for Hematology and Regenerative Medicine
- Douglas Easton
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Paul Pharoah
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Alison Dunning
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Julian Peto
- Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine
- Federico Canzian
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- Anthony Swerdlow
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Rosalind A. Eeles
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- ZSofia Kote-Jarai
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Kenneth Muir
- Institute of Population Health, University of Manchester
- Nora Pashayan
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Jolanta Nickel
- Department of Internal Medicine V, University of Heidelberg
- Markus M. Nöthen
- Institute of Human Genetics, University of Bonn
- Thorunn Rafnar
- deCODE Genetics
- Fiona M. Ross
- Wessex Regional Genetics Laboratory, University of Southampton
- Miguel Inacio da Silva Filho
- German Cancer Research Center
- Hauke Thomsen
- German Cancer Research Center
- Ingemar Turesson
- Hematology Clinic, Skåne University Hospital
- Annette Vangsted
- Department of Haematology, University Hospital of Copenhagen at Rigshospitalet
- Niels Frost Andersen
- Department of Haematology, Aarhus University Hospital
- Anders Waage
- Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology
- Brian A. Walker
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Anna-Karin Wihlborg
- Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund University
- Annemiek Broyl
- Department of Hematology, Erasmus MC Cancer Institute
- Faith E. Davies
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Unnur Thorsteinsdottir
- deCODE Genetics
- Christian Langer
- Department of Internal Medicine III, University of Ulm
- Markus Hansson
- Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund University
- Hartmut Goldschmidt
- Department of Internal Medicine V, University of Heidelberg
- Martin Kaiser
- Division of Molecular Pathology, The Institute of Cancer Research
- Pieter Sonneveld
- Department of Hematology, Erasmus MC Cancer Institute
- Kari Stefansson
- deCODE Genetics
- Gareth J. Morgan
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Kari Hemminki
- German Cancer Research Center
- Björn Nilsson
- Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund University
- Richard S. Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- The PRACTICAL consortium
- DOI
- https://doi.org/10.1038/s41467-018-04989-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Multiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epigenetic profiling and in situ Hi-C data to further our understanding of MM susceptibility.
