A NUMERICAL STUDY OF MAGNETIC NANOPARTICLES HYPERTHERMIA WITH ALTERNATING MAGNETIC FIELD UNDER INFLUENCE OF CONVECTION HEAT TRANSFER

Abstract

In this paper, a numerical study has been conducted to understand the heating effects of the magnetic nanoparticles in the tumor hyperthermia in order to reach a desirable temperature in the tumor. The developed numerical method has been utilized to obtain the temperature distribution and magnetic induction value using the bioheat and Maxwell equations inside a cylindrical geometry including the tumor and healthy tissue while the perfusion and metabolism rates have been considered. Results show that among all the parameters effected on temperature rise, the diameter of the nanoparticles (ranging from 5,5.5,6 nm) has the maximum effect, the strength of the applied alternating current (AC) magnetic field (ranging from 50, 62,75 mT) has the minimum effect, and the volume fraction (ranging from 0.0004,0.0006,0.0008) and the frequency of the applied AC magnetic field (ranging from 300,400,500 kHz) result in increasing the temperature relatively. The temperature rise for a temperature-dependent metabolism is larger than a temperature-independent metabolism. Among the materials investigated in this study, FePt has the most pronounced effect.

Keywords

• Tumor
• Hyperthermia
• Bioheat
• Magnetic nanoparticles
• Induction