Micropeptides translated from putative long non-coding RNAs

Li Junhong; Qu Lei; Sang Lingjie; Wu Xinyu; Jiang Anlan; Liu Jian; Lin Aifu

doi:10.3724/abbs.2022010

Acta Biochimica et Biophysica Sinica (Feb 2022)

Micropeptides translated from putative long non-coding RNAs

Li Junhong,
Qu Lei,
Sang Lingjie,
Wu Xinyu,
Jiang Anlan,
Liu Jian,
Lin Aifu

Affiliations

Li Junhong: ["MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China"]
Qu Lei: ["MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China"]
Sang Lingjie: ["MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China"]
Wu Xinyu: ["Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining 314400, China","Hangzhou Cancer Institution, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310002, China"]
Jiang Anlan: ["Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining 314400, China","Hangzhou Cancer Institution, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310002, China"]
Liu Jian: ["Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining 314400, China","Hangzhou Cancer Institution, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310002, China"]
Lin Aifu: ["MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China","International Institutes of Medicine, the 4th Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, China","Cancer Center, Zhejiang University, Hangzhou 310058, China","Breast Center of the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China","Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Hangzhou 310058, China"]

DOI: https://doi.org/10.3724/abbs.2022010
Journal volume & issue: Vol. 54
pp. 292 – 300

Abstract

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Long non-coding RNAs (lncRNAs) transcribed in mammals and eukaryotes were thought to have no protein coding capability. However, recent studies have suggested that plenty of lncRNAs are mis-annotated and virtually contain coding sequences which are translated into bona fide functional peptides by ribosomal machinery, and these functional peptides are called micropeptides or small peptides. Here we review the rapidly advancing field of micropeptides translated from putative lncRNAs, describe the strategies for their identification, and elucidate their critical roles in many fundamental biological processes. We also discuss the prospects of research in micropeptides and the potential applications of micropeptides.

Published in Acta Biochimica et Biophysica Sinica

ISSN: 1672-9145 (Print); 1745-7270 (Online)
Publisher: China Science Publishing & Media Ltd.
Country of publisher: China
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry; Science: Biology (General): Genetics
Website: https://www.sciengine.com/ABBS/home

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