Journal of Pharmacological Sciences (Jan 2014)

Pharmacological Characterization of Standard Analgesics on Oxaliplatin-Induced Acute Cold Hypersensitivity in Mice

  • Meng Zhao,
  • Saki Nakamura,
  • Takahito Miyake,
  • Kanako So,
  • Hisashi Shirakawa,
  • Shogo Tokuyama,
  • Minoru Narita,
  • Takayuki Nakagawa,
  • Shuji Kaneko

DOI
https://doi.org/10.1254/jphs.13249sc
Journal volume & issue
Vol. 124, no. 4
pp. 514 – 517

Abstract

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Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion. We recently reported that a single administration of oxaliplatin induced cold hypersensitivity 2 h after the administration in mice. In this study, we examined whether standard analgesics relieve the oxaliplatin-induced acute cold hypersensitivity. Gabapentin, tramadol, mexiletine, and calcium gluconate significantly inhibited and morphine and milnacipran decreased the acute cold hypersensitivity, while diclofenac and amitriptyline had no effects. These results suggest that gabapentin, tramadol, mexiletine, and calcium gluconate are effective against oxaliplatin-induced acute peripheral neuropathy. Keywords:: oxaliplatin, acute peripheral neuropathy, analgesic