Detection distribution of CNVs of SNX29 in three goat breeds and their associations with growth traits

Qian Wang; Xiaoyue Song; Xiaoyue Song; Yi Bi; Haijing Zhu; Haijing Zhu; Xianfeng Wu; Zhengang Guo; Mei Liu; Chuanying Pan

doi:10.3389/fvets.2023.1132833

Frontiers in Veterinary Science (Aug 2023)

Detection distribution of CNVs of SNX29 in three goat breeds and their associations with growth traits

Qian Wang,
Xiaoyue Song,
Xiaoyue Song,
Yi Bi,
Haijing Zhu,
Haijing Zhu,
Xianfeng Wu,
Zhengang Guo,
Mei Liu,
Chuanying Pan

Affiliations

Qian Wang: College of Animal Science and Technology, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi, China
Xiaoyue Song: Shaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin, Shaanxi, China
Xiaoyue Song: Life Science Research Center, Yulin University, Yulin, Shaanxi, China
Yi Bi: College of Animal Science and Technology, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi, China
Haijing Zhu: Shaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin, Shaanxi, China
Haijing Zhu: Life Science Research Center, Yulin University, Yulin, Shaanxi, China
Xianfeng Wu: Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian, China
Zhengang Guo: Animal Husbandry and Veterinary Science Institute of Bijie City, Bijie, Guizhou, China
Mei Liu: College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China
Chuanying Pan: College of Animal Science and Technology, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi, China

DOI: https://doi.org/10.3389/fvets.2023.1132833
Journal volume & issue: Vol. 10

Abstract

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As a member of the SNX family, the goat sorting nexin 29 (SNX29) is initially identified as a myogenesis gene. Therefore, this study aimed to examine the polymorphism in the SNX29 gene and its association with growth traits. In this study, we used an online platform to predict the structures of the SNX29 protein and used quantitative real-time PCR to detect potential copy number variation (CNV) in Shaanbei white cashmere (SBWC) goats (n = 541), Guizhou black (GB) goats (n = 48), and Nubian (NB) goats (n = 39). The results showed that goat SNX29 protein belonged to non-secretory protein. Then, five CNVs were detected, and their association with growth traits was analyzed. In SBWC goats, CNV1, CNV3, CNV4, and CNV5 were associated with chest width and body length (P < 0.05). Among them, the CNV1 individuals with gain and loss genotypes were superior to those individuals with a median genotype, but CNV4 and CNV5 of individuals with the median genotype were superior to those with the loss and gain genotypes. In addition, individuals with the gain genotype had superior growth traits in CNV3. In brief, this study suggests that the CNV of SNX29 can be used as a molecular marker in goat breeding.

Published in Frontiers in Veterinary Science

ISSN: 2297-1769 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Agriculture: Animal culture: Veterinary medicine
Website: https://www.frontiersin.org/journals/veterinary-science

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