Journal of Inflammation Research (Apr 2024)

Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis

  • Yang X,
  • Liao L,
  • Liang Z,
  • Yu S,
  • Guo Z

Journal volume & issue
Vol. Volume 17
pp. 2327 – 2335

Abstract

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Xiaoyan Yang,1 Liyin Liao,1 Zizhen Liang,1 Shenglong Yu,2 Zhonghui Guo1 1Department of Laboratory Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, People’s Republic of China; 2Institute of Cardiovascular Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, People’s Republic of ChinaCorrespondence: Zhonghui Guo, Department of Laboratory Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, No. 8, Fuyu East Road, Qiaonan Street, Panyu District, Guangzhou, 511400, People’s Republic of China, Tel +86 20 3485 8850, Email [email protected]: This research aimed to explore the involvement of interleukins (IL) - IL-6, IL-17, IL-21, and IL-23 - in the evolution and diagnosis of non-alcoholic liver fibrosis and cirrhosis.Methods: The study subjects were selected from the patients who visited the Department of Hepatology of X Hospital in Y City from August 2021 to April 2023. Peripheral blood samples were collected. All participants were divided into liver fibrosis, cirrhosis, hepatitis, and healthy subjects four groups. IL-21, IL-17, IL23, IL-6 were detected by double antibody sandwich.Results: The results showed that there was a significant difference in the levels of IL-17, IL-21, and IL-23 among the 4 groups (P 0.70, suggesting that the diagnostic efficacy of IL-17, IL-21 was similar to that of liver fiber 4 items. Spearman correlation analysis showed that IL-17 had a positive correlation with collagen type III N-peptide, type IV collagen, and Laminin (P 0.05).Conclusion: IL-17, IL-21, and IL-23 play a pivotal role in the inflammatory pathways associated with liver injuries, establishing themselves as potent auxiliary diagnostic markers in identifying liver fibrosis and cirrhosis.Keywords: non-alcoholic liver fibrosis, cirrhosis, diagnostic markers, cytokines

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