International Journal of Nanomedicine (Jul 2023)
Research Progress of Design Drugs and Composite Biomaterials in Bone Tissue Engineering
Abstract
Xinghua Guo,1,2,* Pan Song,1,2,* Feng Li,1,2,* Qihao Yan,1,2,* Yan Bai,3 Jincan He,3 Qishi Che,4 Hua Cao,5 Jiao Guo,2 Zhengquan Su1 1Guangdong Engineering Research Center of Natural Products and New Drugs, Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China; 2Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China; 3School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510310, People’s Republic of China; 4Guangzhou Rainhome Pharm & Tech Co., Ltd, Science City, Guangzhou, 510663, People’s Republic of China; 5School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, 528458, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhengquan Su, Guangdong Engineering Research Center of Natural Products and New Drugs, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China, Tel +86-20-3935-2067, Fax +86-20-3935-2067, Email [email protected]: Bone, like most organs, has the ability to heal naturally and can be repaired slowly when it is slightly injured. However, in the case of bone defects caused by diseases or large shocks, surgical intervention and treatment of bone substitutes are needed, and drugs are actively matched to promote osteogenesis or prevent infection. Oral administration or injection for systemic therapy is a common way of administration in clinic, although it is not suitable for the long treatment cycle of bone tissue, and the drugs cannot exert the greatest effect or even produce toxic and side effects. In order to solve this problem, the structure or carrier simulating natural bone tissue is constructed to control the loading or release of the preparation with osteogenic potential, thus accelerating the repair of bone defect. Bioactive materials provide potential advantages for bone tissue regeneration, such as physical support, cell coverage and growth factors. In this review, we discuss the application of bone scaffolds with different structural characteristics made of polymers, ceramics and other composite materials in bone regeneration engineering and drug release, and look forward to its prospect.Graphical Abstract: Keywords: bone scaffold, drug loading, slow release, osteogenesis, biomaterial
