Time course gene expression data in colon of mice after exposure to food-grade E171
Héloïse Proquin,
Marlon J. Jetten,
Marloes C.M. Jonkhout,
Luis G. Garduño-Balderas,
Jacob J. Briedé,
Theo M. de Kok,
Yolanda I. Chirino,
Henk van Loveren
Affiliations
Héloïse Proquin
Department of Toxicogenomics, GROW Institute of Oncology and Developmental Biology, Maastricht University, The Netherlands; Corresponding author. Fax: +31 43 3884146.
Marlon J. Jetten
Department of Toxicogenomics, GROW Institute of Oncology and Developmental Biology, Maastricht University, The Netherlands
Marloes C.M. Jonkhout
Department of Toxicogenomics, GROW Institute of Oncology and Developmental Biology, Maastricht University, The Netherlands
Luis G. Garduño-Balderas
Laboratorio de Carcinogénesis y Toxicología, Unidad de Biomedicina, FES-Iztacala, UNAM, Estado de México, Mexico
Jacob J. Briedé
Department of Toxicogenomics, GROW Institute of Oncology and Developmental Biology, Maastricht University, The Netherlands
Theo M. de Kok
Department of Toxicogenomics, GROW Institute of Oncology and Developmental Biology, Maastricht University, The Netherlands
Yolanda I. Chirino
Laboratorio de Carcinogénesis y Toxicología, Unidad de Biomedicina, FES-Iztacala, UNAM, Estado de México, Mexico; IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 DE Düsseldorf, Germany
Henk van Loveren
Department of Toxicogenomics, GROW Institute of Oncology and Developmental Biology, Maastricht University, The Netherlands
We investigated gene expression responses in BALB/c mice exposed by gavage to 5 mg/kg bw/day of E171 for 2, 7, 14 and 21 days. Food additive E171 (titanium dioxide) has been shown to induce oxidative stress and DNA damage in vitro as well as facilitating growth of colorectal tumours in vivo. Full genome expression changes of the colon of mice were investigated by using Agilent SurePrint G3 mouse Gene exp 60kv2 microarrays slides. The data presented in this DiB include all differentially expressed for each time point with EntrezGeneID, gene symbols, gene names and Log2FC as well as genes included in pathways after over-representation analysis in ConsensusPathDataBase. The functions of these genes in relation to the colon were described in our associated article (Proquin et al., 2017 in press) [1]. Raw and normalized gene expression data are available through NCBI GEO (GEO accession: GSE92563).
