Nature Communications (Sep 2022)
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner
- Tatiana Dandolini Saccon,
- Felippe Mousovich-Neto,
- Raissa Guimarães Ludwig,
- Victor Corasolla Carregari,
- Ana Beatriz dos Anjos Souza,
- Amanda Stephane Cruz dos Passos,
- Matheus Cavalheiro Martini,
- Priscilla Paschoal Barbosa,
- Gabriela Fabiano de Souza,
- Stéfanie Primon Muraro,
- Julia Forato,
- Mariene Ribeiro Amorim,
- Rafael Elias Marques,
- Flavio Protasio Veras,
- Ester Barreto,
- Tiago Tomazini Gonçalves,
- Isadora Marques Paiva,
- Narayana P. B. Fazolini,
- Carolina Mie Kawagosi Onodera,
- Ronaldo Bragança Martins Junior,
- Paulo Henrique Cavalcanti de Araújo,
- Sabrina Setembre Batah,
- Rosa Maria Mendes Viana,
- Danilo Machado de Melo,
- Alexandre Todorovic Fabro,
- Eurico Arruda,
- Fernando Queiroz Cunha,
- Thiago Mattar Cunha,
- Marco Antônio M. Pretti,
- Bradley Joseph Smith,
- Henrique Marques-Souza,
- Thiago L. Knittel,
- Gabriel Palermo Ruiz,
- Gerson S. Profeta,
- Tereza Cristina Minto Fontes-Cal,
- Mariana Boroni,
- Marco Aurélio Ramirez Vinolo,
- Alessandro S. Farias,
- Pedro Manoel M. Moraes-Vieira,
- Joyce Maria Annichino Bizzacchi,
- Tambet Teesalu,
- Felipe David Mendonça Chaim,
- Everton Cazzo,
- Elinton Adami Chaim,
- José Luiz Proença-Módena,
- Daniel Martins-de-Souza,
- Mariana Kiomy Osako,
- Luiz Osório Leiria,
- Marcelo A. Mori
Affiliations
- Tatiana Dandolini Saccon
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Felippe Mousovich-Neto
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Raissa Guimarães Ludwig
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Victor Corasolla Carregari
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Ana Beatriz dos Anjos Souza
- Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo
- Amanda Stephane Cruz dos Passos
- Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo
- Matheus Cavalheiro Martini
- Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Priscilla Paschoal Barbosa
- Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Gabriela Fabiano de Souza
- Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Stéfanie Primon Muraro
- Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Julia Forato
- Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Mariene Ribeiro Amorim
- Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Rafael Elias Marques
- Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM)
- Flavio Protasio Veras
- Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo
- Ester Barreto
- Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo
- Tiago Tomazini Gonçalves
- Center for Research in Inflammatory Diseases
- Isadora Marques Paiva
- Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo
- Narayana P. B. Fazolini
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Carolina Mie Kawagosi Onodera
- Hematology-Hemotherapy Center, University of Campinas
- Ronaldo Bragança Martins Junior
- Virology Research Center, Ribeirão Preto Medical School, University of São Paulo
- Paulo Henrique Cavalcanti de Araújo
- Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo
- Sabrina Setembre Batah
- Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo
- Rosa Maria Mendes Viana
- Virology Research Center, Ribeirão Preto Medical School, University of São Paulo
- Danilo Machado de Melo
- Virology Research Center, Ribeirão Preto Medical School, University of São Paulo
- Alexandre Todorovic Fabro
- Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo
- Eurico Arruda
- Virology Research Center, Ribeirão Preto Medical School, University of São Paulo
- Fernando Queiroz Cunha
- Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo
- Thiago Mattar Cunha
- Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo
- Marco Antônio M. Pretti
- Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA)
- Bradley Joseph Smith
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Henrique Marques-Souza
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Thiago L. Knittel
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Gabriel Palermo Ruiz
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Gerson S. Profeta
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Tereza Cristina Minto Fontes-Cal
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Mariana Boroni
- Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA)
- Marco Aurélio Ramirez Vinolo
- Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Alessandro S. Farias
- Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Pedro Manoel M. Moraes-Vieira
- Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Joyce Maria Annichino Bizzacchi
- Hematology-Hemotherapy Center, University of Campinas
- Tambet Teesalu
- Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu
- Felipe David Mendonça Chaim
- Department of Surgery, Faculty of Medical Sciences, University of Campinas
- Everton Cazzo
- Department of Surgery, Faculty of Medical Sciences, University of Campinas
- Elinton Adami Chaim
- Department of Surgery, Faculty of Medical Sciences, University of Campinas
- José Luiz Proença-Módena
- Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Daniel Martins-de-Souza
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- Mariana Kiomy Osako
- Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo
- Luiz Osório Leiria
- Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo
- Marcelo A. Mori
- Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
- DOI
- https://doi.org/10.1038/s41467-022-33218-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Visceral adiposity is a risk factor for severe COVID-19, and infection of adipose tissue by SARS-CoV-2 has been reported. Here the authors confirm that human adipose tissue is a possible site for SARS-CoV-2 infection, but the degree of adipose tissue infection and the way adipocytes respond to the virus depend on the adipose tissue depot and the viral strain.
