Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis

Abstract

Jennifer Karlow et al. characterize the DNA methylation changes in two unrelated cancer types. They find that both cancers show methylation changes in regulatory regions corresponding to the cancer’s tissue of origin, suggesting that loss of cellular identity may be an important step in tumorigeneses shared across cancers.