Diabetes mellitus and chronic liver diseases. Part 1: general mechanisms of etiology and pathogenesis

Abstract

In recent years there has been an active discussion about the relationship between diabetes mellitus (DM) and chronic liver diseases (CLD). On the one hand, patients with diabetes have an increased risk of developing CLD. On the other hand, patients with CLD very often identify abnormal glucose metabolism which ultimately leads to impaired glucose tolerance and the development of diabetes. This review outlines potential causal relationships between some CLD and DM. Common mechanisms that provoke metabolic and autoimmune disorders in the development of various nosologies of the CKD group, leading to steatosis, insulin resistance, impaired glucose tolerance and the development of diabetes are described. Certain features of the assessment of carbohydrate metabolism compensation in patients with hepatic dysfunction, anemia and protein metabolism disorders are described.

Keywords

• diabetes mellitus
• chronic liver diseases
• liver failure
• cirrhosis
• viral hepatitis
• alcoholic liver disease
• non alcoholic fatty liver disease
• insulin resistance
• hypoglycemic drugs