Nature Communications (Apr 2021)

Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals

  • Huishan Tao,
  • Yun Pan,
  • Shuai Chu,
  • Lei Li,
  • Jinhai Xie,
  • Peng Wang,
  • Shimeng Zhang,
  • Srija Reddy,
  • John W. Sleasman,
  • Xiao-Ping Zhong

DOI
https://doi.org/10.1038/s41467-021-22162-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 21

Abstract

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Mucosal-associated invariant T (MAIT) cells are key in immunity and diseases, but how their effector polarization is controlled is still unclear. Here, the authors show that an IL-1β/IL-23/mTORC2 axis is essential for the induction of IL-17-producing MAIT17, while an IL-2/IL-15/mTORC1 axis is important for the homeostasis of IFN-γ-producing MAIT1.