Antihypertensive Effects of Artemisia scoparia Waldst in Spontaneously Hypertensive Rats and Identification of Angiotensin I Converting Enzyme Inhibitors
Jeong-Yong Cho,
Kyung-Hee Park,
Do Young Hwang,
Saoraya Chanmuang,
Lily Jaiswal,
Yang-Kyun Park,
Sun-Young Park,
So-Young Kim,
Haeng-Ran Kim,
Jae-Hak Moon,
Kyung-Sik Ham
Affiliations
Jeong-Yong Cho
Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea
Kyung-Hee Park
Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea
Do Young Hwang
Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea
Saoraya Chanmuang
Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea
Lily Jaiswal
Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea
Yang-Kyun Park
Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea
Sun-Young Park
Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea
So-Young Kim
Division of Functional Food & Nutrition, National Academy of Agricultural Sciences, Rural Development Administration (RDA), Jeonbuk 560-500, Korea
Haeng-Ran Kim
Division of Functional Food & Nutrition, National Academy of Agricultural Sciences, Rural Development Administration (RDA), Jeonbuk 560-500, Korea
Jae-Hak Moon
Department of Food Science & Technology, and Functional Food Research Center, Chonnam National University, Gwangju 500-757, Korea
Kyung-Sik Ham
Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea
We investigated the antihypertensive effects of Artemisia scoparia (AS) in spontaneously hypertensive rats (SHR). The rats were fed diets containing 2% (w/w) hot water extracts of AS aerial parts for 6 weeks. The AS group had significantly lower systolic and diastolic blood pressure levels than the control group. The AS group also had lower angiotensin I converting enzyme (ACE) activity and angiotensin II content in serum compared to the control group. The AS group showed higher vascular endothelial growth factor and lower ras homolog gene family member A expression levels in kidney compared to the control group. The AS group had significantly lower levels of plasma lipid oxidation and protein carbonyls than the control group. One new and six known compounds were isolated from AS by guided purification. The new compound was determined to be 4′-O-β-D-glucopyranoyl (E)-4-hydroxy-3-methylbut-2-enyl benzoate, based on its nuclear magnetic resonance and electrospray ionization-mass spectroscopy data.
