Journal of Cardiovascular Magnetic Resonance (Jan 2013)

Correction with blood T1 is essential when measuring post-contrast myocardial T1 value in patients with acute myocardial infarction

  • Choi Eui-Young,
  • Hwang Sung Ho,
  • Yoon Young Won,
  • Park Chul Hwan,
  • Paek Mun Young,
  • Greiser Andreas,
  • Chung Hyemoon,
  • Yoon Ji-Hyun,
  • Kim Jong-Youn,
  • Min Pil-Ki,
  • Lee Byoung Kwon,
  • Hong Bum-Kee,
  • Rim Se-Joong,
  • Kwon Hyuck Moon,
  • Kim Tae Hoon

DOI
https://doi.org/10.1186/1532-429X-15-11
Journal volume & issue
Vol. 15, no. 1
p. 11

Abstract

Read online

Abstract Background Post-contrast T1 mapping by modified Look-Locker inversion recovery (MOLLI) sequence has been introduced as a promising means to assess an expansion of the extra-cellular space. However, T1 value in the myocardium can be affected by scanning time after bolus contrast injection. In this study, we investigated the changes of the T1 values according to multiple slicing over scanning time at 15 minutes after contrast injection and usefulness of blood T1 correction. Methods Eighteen reperfused acute myocardial infarction (AMI) patients, 13 cardiomyopathy patients and 8 healthy volunteers underwent cardiovascular magnetic resonance with 15 minute-post contrast MOLLI to generate T1 maps. In 10 cardiomyopathy cases, pre- and post-contrast MOLLI techniques were performed to generate extracellular volume fraction (Ve). Six slices of T1 maps according to the left ventricular (LV) short axis, from apex to base, were consecutively obtained. Each T1 value was measured in the whole myocardium, infarcted myocardium, non-infarcted myocardium and LV blood cavity. Results The mean T1 value of infarcted myocardium was significantly lower than that of non-infarcted myocardium (425.4±68.1 ms vs. 540.5±88.0 ms, respectively, p0.05). The Ve did not show significant differences from apical to basal slices. Conclusion Post-contrast myocardial T1 corrected by blood T1 or Ve, provide more stable measurement of degree of fibrosis in non-infarcted myocardium in short- axis multiple slicing.

Keywords