Nature Communications (Aug 2017)
A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis
- Sarah L. Rouse,
- William J. Hawthorne,
- Jamie-Lee Berry,
- Dror S. Chorev,
- Sandra A. Ionescu,
- Sebastian Lambert,
- Fisentzos Stylianou,
- Wiebke Ewert,
- Uma Mackie,
- R. Marc L. Morgan,
- Daniel Otzen,
- Florian-Alexander Herbst,
- Per H. Nielsen,
- Morten Dueholm,
- Hagan Bayley,
- Carol V. Robinson,
- Stephen Hare,
- Stephen Matthews
Affiliations
- Sarah L. Rouse
- Department of Life Sciences, Imperial College London, South Kensington Campus
- William J. Hawthorne
- Department of Life Sciences, Imperial College London, South Kensington Campus
- Jamie-Lee Berry
- Department of Life Sciences, Imperial College London, South Kensington Campus
- Dror S. Chorev
- Chemistry Research Laboratory, University of Oxford
- Sandra A. Ionescu
- Chemistry Research Laboratory, University of Oxford
- Sebastian Lambert
- Duke-NUS Medical School
- Fisentzos Stylianou
- Department of Life Sciences, Imperial College London, South Kensington Campus
- Wiebke Ewert
- Department of Life Sciences, Imperial College London, South Kensington Campus
- Uma Mackie
- Department of Life Sciences, Imperial College London, South Kensington Campus
- R. Marc L. Morgan
- Department of Life Sciences, Imperial College London, South Kensington Campus
- Daniel Otzen
- Interdisciplinary Nanoscience Center (iNANO), Centre for Insoluble Protein Structures (inSPIN), Department of Molecular Biology and Genetics, Aarhus University
- Florian-Alexander Herbst
- Center for Microbial Communities, Department of Chemistry and Bioscience, Aalborg University
- Per H. Nielsen
- Center for Microbial Communities, Department of Chemistry and Bioscience, Aalborg University
- Morten Dueholm
- Center for Microbial Communities, Department of Chemistry and Bioscience, Aalborg University
- Hagan Bayley
- Chemistry Research Laboratory, University of Oxford
- Carol V. Robinson
- Chemistry Research Laboratory, University of Oxford
- Stephen Hare
- Department of Life Sciences, Imperial College London, South Kensington Campus
- Stephen Matthews
- Department of Life Sciences, Imperial College London, South Kensington Campus
- DOI
- https://doi.org/10.1038/s41467-017-00361-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Gram-negative bacteria assemble biofilms from amyloid fibres, which translocate across the outer membrane as unfolded amyloid precursors through a secretion system. Here, the authors characterise the structural details of the amyloid transporter FapF in Pseudomonas.
