A short-term high-sugar diet is an aggravating factor in experimental allergic contact dermatitis
Leila F. Coêlho,
Mateus B. Casaro,
Willian R. Ribeiro,
Eduardo Mendes,
Gilson Murata,
Patrícia Xander,
Adriana Lino-dos-Santos-Franco,
Fernando A. Oliveira,
Caroline M. Ferreira
Affiliations
Leila F. Coêlho
Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
Mateus B. Casaro
Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
Willian R. Ribeiro
Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
Eduardo Mendes
Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
Gilson Murata
Nephrology Division, Medical Investigation Laboratory-29 (LIM-29), Medical School, University of São Paulo (FM-USP), São Paulo, Brazil
Patrícia Xander
Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
Adriana Lino-dos-Santos-Franco
Post Graduate Program in Biophotonics Medicine, University Nove de Julho (UNINOVE), São Paulo, Brazil
Fernando A. Oliveira
Cellular and Molecular Neurobiology Laboratory (LaNeC) - Center for Mathematics, Computing and Cognition (CMCC), Federal University of ABC (UFABC), São Bernardo do Campo, Brazil
Caroline M. Ferreira
Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Corresponding author. Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Federal University of São Paulo, R. São Nicolau, 210, Diadema, SP, 09913-03, Brazil.
Allergic contact dermatitis (ACD) is an inflammatory skin reaction whose incidence has increased and has been associated with a dietary pattern rich in saturated fats and refined sugars. Considering the increased incidence of ACD and the lack of research about the influence of a short-term high-sugar diet on dermatitis, our aim is to improve understanding of the influence of a high-sugar diet on ACD. We introduced a diet rich in sugar fifteen days before inducing contact dermatitis with oxazolone, in mice, and maintained it until the end of the experiment, which lasted three weeks in total. The dermatitis model increased cholesterol and triglycerides in the liver, and the combination of diet and dermatitis increased weight and worsened liver cholesterol measurements. Furthermore, the high-sugar diet increased the production of IL-6, IFN-γ and TNF-α in the skin, which may be involved in the increase in epithelial skin thickness observed in experimental ACD.
