Macromolecular-clustered facial amphiphilic antimicrobials

Md Anisur Rahman; Marpe Bam; Edgar Luat; Moumita Sharmin Jui; Mitra S. Ganewatta; Tinom Shokfai; Mitzi Nagarkatti; Alan W. Decho; Chuanbing Tang

doi:10.1038/s41467-018-07651-7

Nature Communications (Dec 2018)

Macromolecular-clustered facial amphiphilic antimicrobials

Md Anisur Rahman,
Marpe Bam,
Edgar Luat,
Moumita Sharmin Jui,
Mitra S. Ganewatta,
Tinom Shokfai,
Mitzi Nagarkatti,
Alan W. Decho,
Chuanbing Tang

Affiliations

Md Anisur Rahman: Department of Chemistry and Biochemistry
Marpe Bam: Department of Pathology, Microbiology and Immunology, University of South Carolina, School of Medicine
Edgar Luat: Department of Chemistry and Biochemistry
Moumita Sharmin Jui: Department of Chemistry and Biochemistry
Mitra S. Ganewatta: Department of Chemistry and Biochemistry
Tinom Shokfai: Department of Environmental Health Sciences, University of South Carolina
Mitzi Nagarkatti: Department of Pathology, Microbiology and Immunology, University of South Carolina, School of Medicine
Alan W. Decho: Department of Environmental Health Sciences, University of South Carolina
Chuanbing Tang: Department of Chemistry and Biochemistry

DOI: https://doi.org/10.1038/s41467-018-07651-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Bacterial infections and antibiotic resistance are an increasing concern for the world. Here the authors report a class of cationic antimicrobial polymers that cluster local facial amphiphilicity from repeating units to enhance interactions with bacterial membranes without requiring a high unfavorable entropic loss.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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