DNA dynamics and computation based on toehold-free strand displacement

Hong Kang; Tong Lin; Xiaojin Xu; Qing-Shan Jia; Richard Lakerveld; Bryan Wei

doi:10.1038/s41467-021-25270-7

Nature Communications (Aug 2021)

DNA dynamics and computation based on toehold-free strand displacement

Hong Kang,
Tong Lin,
Xiaojin Xu,
Qing-Shan Jia,
Richard Lakerveld,
Bryan Wei

Affiliations

Hong Kang: School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University
Tong Lin: School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University
Xiaojin Xu: Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay
Qing-Shan Jia: Center for Intelligent and Networked Systems, Department of Automation, Beijing National Research Center for Information Science and Technology (BNRist), Tsinghua University
Richard Lakerveld: Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay
Bryan Wei: School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University

DOI: https://doi.org/10.1038/s41467-021-25270-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

Read online

Synthetic DNA constructs can to used to recognise and respond to input signals. Here the authors present complex DNA nanostructures with toehold-free strand displacement for generation of ON/OFF switches and Boolean gates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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