Phytochemical Analysis and <i>In Vitro</i> Antileukemic Activity of Alkaloid-Enriched Extracts from <i>Vinca sardoa</i> (Stearn) Pignatti
Daniela De Vita,
Claudio Frezza,
Fabio Sciubba,
Chiara Toniolo,
Camilla Badiali,
Rita Petrucci,
Martina Bortolami,
Paola Di Matteo,
Daniele Rocco,
Annarita Stringaro,
Marisa Colone,
Andrea Maxia,
Maria Teresa Petrucci,
Mauro Serafini,
Sebastiano Foddai
Affiliations
Daniela De Vita
Department of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Claudio Frezza
Department of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Fabio Sciubba
Department of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Chiara Toniolo
Department of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Camilla Badiali
Department of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Rita Petrucci
Department of Basic and Applied Sciences for Engineering, “Sapienza” University of Rome, Via Castro Laurenziano 7, 00161 Rome, Italy
Martina Bortolami
Department of Basic and Applied Sciences for Engineering, “Sapienza” University of Rome, Via Castro Laurenziano 7, 00161 Rome, Italy
Paola Di Matteo
Department of Basic and Applied Sciences for Engineering, “Sapienza” University of Rome, Via Castro Laurenziano 7, 00161 Rome, Italy
Daniele Rocco
Department of Basic and Applied Sciences for Engineering, “Sapienza” University of Rome, Via Castro Laurenziano 7, 00161 Rome, Italy
Annarita Stringaro
National Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy
Marisa Colone
National Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy
Andrea Maxia
Laboratory of Economic and Pharmaceutical Botany, Department of Life and Environmental Sciences, University of Cagliari, Viale S. Ignazio da Laconi 13, 09123 Cagliari, Italy
Maria Teresa Petrucci
Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome, Via Benevento 6, 00161 Rome, Italy
Mauro Serafini
Department of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Sebastiano Foddai
Department of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.
