Bone-derived excess TGF-ß release is associated with cognitive dysfunction due to oxidation of RyR, Ca2+ leak and mitochondrial dysfunction

• Lei Shi,
• Sukanya Suresh,
• Truc Kuo,
• Anand Singh,
• Jade Martinez,
• Trupti Trivedi,
• Gabriel M. Pagnotti,
• Leah D. Guerra,
• Xu Cao,
• Theresa A. Guise

Affiliations

Lei Shi

Department of Endocrine Neoplasia and HD, Houston, TX 77030, USA

Sukanya Suresh

Department of Endocrine Neoplasia and HD, Houston, TX 77030, USA

Truc Kuo

Department of Endocrine Neoplasia and HD, Houston, TX 77030, USA

Anand Singh

Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

Jade Martinez

Department of Endocrine Neoplasia and HD, Houston, TX 77030, USA

Trupti Trivedi

Department of Endocrine Neoplasia and HD, Houston, TX 77030, USA

Gabriel M. Pagnotti

Department of Endocrine Neoplasia and HD, Houston, TX 77030, USA

Leah D. Guerra

Department of Endocrine Neoplasia and HD, Houston, TX 77030, USA

Xu Cao

Department of Department of Orthopedic Surgery, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA

Theresa A. Guise

Department of Endocrine Neoplasia and HD, Houston, TX 77030, USA