Nature Communications (Oct 2019)

Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease

  • Sarah Gooding,
  • Sam W. Z. Olechnowicz,
  • Emma V. Morris,
  • Andrew E. Armitage,
  • Joao Arezes,
  • Joe Frost,
  • Emmanouela Repapi,
  • James R. Edwards,
  • Neil Ashley,
  • Craig Waugh,
  • Nicola Gray,
  • Erik Martinez-Hackert,
  • Pei Jin Lim,
  • Sant-Rayn Pasricha,
  • Helen Knowles,
  • Adam J. Mead,
  • Karthik Ramasamy,
  • Hal Drakesmith,
  • Claire M. Edwards

DOI
https://doi.org/10.1038/s41467-019-12296-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone-disease