Stem Cells International (Jan 2024)

Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Promote the Repair of Endometrial Injury via the miR-21-5p/PTEN/AKT Axis

  • Ziwei Li,
  • Hao Ding,
  • Liu Dong,
  • Xiaohua Jiang,
  • Xuan Xu,
  • Zhen Yu,
  • Qiong Xing,
  • Heng Tang,
  • Zhaolian Wei,
  • Jianye Wang

DOI
https://doi.org/10.1155/sci/7674219
Journal volume & issue
Vol. 2024

Abstract

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Conclusion: hUCMSC-Exos ameliorated the damaged uterus, increased the number of glands and embryo implantation rates, suppressed apoptosis, and improved the cell proliferation in the mouse injured endometrium model. Exosomal miR-21-5p positively regulated the repair of endometrial injury and enhances the therapeutic effect of hUCMSC-Exos by activate the PTEN/AKT signaling pathways.