Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD

Narihiro Okazaki, M.D., Ph.D.; Andrew J Burghardt, B.S.; Ko Chiba, M.D., Ph.D.; Anne L Schafer, M.D.; Sharmila Majumdar, Ph.D.

Bone Reports (Dec 2016)

Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD

Narihiro Okazaki, M.D., Ph.D.,
Andrew J Burghardt, B.S.,
Ko Chiba, M.D., Ph.D.,
Anne L Schafer, M.D.,
Sharmila Majumdar, Ph.D.

Affiliations

Narihiro Okazaki, M.D., Ph.D.: Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA; Department of Orthopaedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan; Corresponding author at: 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Andrew J Burghardt, B.S.: Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA
Ko Chiba, M.D., Ph.D.: Department of Orthopaedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan
Anne L Schafer, M.D.: Medical Service, San Francisco VA Medical Center, USA; Department of Medicine, University of California, San Francisco, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
Sharmila Majumdar, Ph.D.: Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA

Journal volume & issue: Vol. 5
pp. 312 – 319

Abstract

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Purpose: The primary objective of this study was to analyze the relationships between bone microstructure and strength, and male osteoporosis risk factors including age, body mass index, serum 25-hydroxyvitamin D level, and testosterone level. A secondary objective was to compare microstructural and strength parameters between men with normal, low, and osteoporosis-range areal bone mineral density (aBMD). Methods: Seventy-eight healthy male volunteers (mean age 62.4 ± 7.8 years, range 50–84 years) were recruited. The participants underwent dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) of the ultra-distal radius and tibia. From the HR-pQCT images, volumetric bone mineral density (BMD) and cortical and trabecular bone microstructure were evaluated, and bone strength and cortical load fraction (Ct.LF) were estimated using micro-finite element analysis (μFEA). Results: Age was more strongly correlated with bone microstructure than other risk factors. Age had significant positive correlations with cortical porosity at both ultra-distal radius and tibia (r = 0.36, p = 0.001, and r = 0.47, p < 0.001, respectively). At the tibia, age was negatively correlated with cortical BMD, whereas it was positively correlated with trabecular BMD. In μFEA, age was negatively correlated with Ct.LF, although not with bone strength. Compared with men with normal aBMD, men with low or osteoporosis-range aBMD had significantly poor trabecular bone microstructure and lower bone strength at the both sites, while there was no significant difference in cortical bone. Conclusions: Cortical bone microstructure was negatively affected by aging, and there was a suggestion that the influence of aging may be particularly important at the weight-bearing sites. Keywords: Male osteoporosis, HR-pQCT, Aging, Cortical porosity, Cortical bone

Published in Bone Reports

ISSN: 2352-1872 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the musculoskeletal system
Website: http://www.journals.elsevier.com/bone-reports/

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