Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling

Homa Rahnamoun; Hanbin Lu; Sascha H. Duttke; Christopher Benner; Christopher K. Glass; Shannon M. Lauberth

doi:10.1038/s41467-017-01117-y

Nature Communications (Sep 2017)

Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling

Homa Rahnamoun,
Hanbin Lu,
Sascha H. Duttke,
Christopher Benner,
Christopher K. Glass,
Shannon M. Lauberth

Affiliations

Homa Rahnamoun: Section of Molecular Biology, University of California, San Diego
Hanbin Lu: Section of Molecular Biology, University of California, San Diego
Sascha H. Duttke: Department of Cellular and Molecular Medicine, University of California, San Diego
Christopher Benner: Department of Cellular and Molecular Medicine, University of California, San Diego
Christopher K. Glass: Department of Cellular and Molecular Medicine, University of California, San Diego
Shannon M. Lauberth: Section of Molecular Biology, University of California, San Diego

DOI: https://doi.org/10.1038/s41467-017-01117-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Inflammation is known to affect cancer development, yet the mechanisms by which immune signaling drives transformation remain unclear. Here, the authors provide evidence that chronic TNF-α signaling promotes the enhancer binding and transcriptional interplay between mutant p53 and NFκB.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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