Marine Drugs
(Feb 2015)
Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
Yin-Di Su,
Tzu-Rong Su,
Zhi-Hong Wen,
Tsong-Long Hwang,
Lee-Shing Fang,
Jih-Jung Chen,
Yang-Chang Wu,
Jyh-Horng Sheu,
Ping-Jyun Sung
Affiliations
Yin-Di Su
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Tzu-Rong Su
Department of Beauty Science, Meiho University, Pingtung 912, Taiwan
Zhi-Hong Wen
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Tsong-Long Hwang
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Lee-Shing Fang
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
Jih-Jung Chen
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
Yang-Chang Wu
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Jyh-Horng Sheu
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Ping-Jyun Sung
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
DOI
https://doi.org/10.3390/md13021037
Journal volume & issue
Vol. 13,
no. 2
Abstract
Read online
Two new briarane-type diterpenoids, briarenolides K (1) and L (2), were isolated from an octocoral identified as Briareum sp. The structures of new briaranes 1 and 2 were elucidated by spectroscopic methods. In the in vitro anti-inflammatory effects test, briaranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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