Structural basis for late maturation steps of the human mitoribosomal large subunit

Miriam Cipullo; Genís Valentín Gesé; Anas Khawaja; B. Martin Hällberg; Joanna Rorbach

doi:10.1038/s41467-021-23617-8

Nature Communications (Jun 2021)

Structural basis for late maturation steps of the human mitoribosomal large subunit

Miriam Cipullo,
Genís Valentín Gesé,
Anas Khawaja,
B. Martin Hällberg,
Joanna Rorbach

Affiliations

Miriam Cipullo: Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet
Genís Valentín Gesé: Department of Cell and Molecular Biology, Karolinska Institutet
Anas Khawaja: Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet
B. Martin Hällberg: Department of Cell and Molecular Biology, Karolinska Institutet
Joanna Rorbach: Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet

DOI: https://doi.org/10.1038/s41467-021-23617-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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