Nature Communications (Oct 2016)
Genome-wide compendium and functional assessment of in vivo heart enhancers
- Diane E. Dickel,
- Iros Barozzi,
- Yiwen Zhu,
- Yoko Fukuda-Yuzawa,
- Marco Osterwalder,
- Brandon J. Mannion,
- Dalit May,
- Cailyn H. Spurrell,
- Ingrid Plajzer-Frick,
- Catherine S. Pickle,
- Elizabeth Lee,
- Tyler H. Garvin,
- Momoe Kato,
- Jennifer A. Akiyama,
- Veena Afzal,
- Ah Young Lee,
- David U. Gorkin,
- Bing Ren,
- Edward M. Rubin,
- Axel Visel,
- Len A. Pennacchio
Affiliations
- Diane E. Dickel
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Iros Barozzi
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Yiwen Zhu
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Yoko Fukuda-Yuzawa
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Marco Osterwalder
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Brandon J. Mannion
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Dalit May
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Cailyn H. Spurrell
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Ingrid Plajzer-Frick
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Catherine S. Pickle
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Elizabeth Lee
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Tyler H. Garvin
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Momoe Kato
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Jennifer A. Akiyama
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Veena Afzal
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Ah Young Lee
- Ludwig Institute for Cancer Research
- David U. Gorkin
- Ludwig Institute for Cancer Research
- Bing Ren
- Ludwig Institute for Cancer Research
- Edward M. Rubin
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Axel Visel
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- Len A. Pennacchio
- Functional Genomics Department, Lawrence Berkeley National Laboratory
- DOI
- https://doi.org/10.1038/ncomms12923
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Identification of non-coding variants has outstripped our ability to annotate and interpret them. Dickel et al. present a compendium of over 80,000 putative human heart enhancers and demonstrate that two conserved enhancers are required for proper cardiac function in mice.
