Cancers (Jun 2023)
Prediction of Prostate Cancer Biochemical and Clinical Recurrence Is Improved by IHC-Assisted Grading Using Appl1, Sortilin and Syndecan-1
- Jessica M. Logan,
- Ashley M. Hopkins,
- Carmela Martini,
- Alexandra Sorvina,
- Prerna Tewari,
- Sarita Prabhakaran,
- Chelsea Huzzell,
- Ian R. D. Johnson,
- Shane M. Hickey,
- Ben S.-Y. Ung,
- Joanna Lazniewska,
- Robert D. Brooks,
- Courtney R. Moore,
- Maria C. Caruso,
- Litsa Karageorgos,
- Cara M. Martin,
- Sharon O’Toole,
- Laura Bogue Edgerton,
- Mark P. Ward,
- Mark Bates,
- Stavros Selemidis,
- Adrian Esterman,
- Sheena Heffernan,
- Helen Keegan,
- Sarah Ní Mhaolcatha,
- Roisin O’Connor,
- Victoria Malone,
- Marguerite Carter,
- Katie Ryan,
- Andres Clarke,
- Nathan Brady,
- Sonja Klebe,
- Hemamali Samaratunga,
- Brett Delahunt,
- Michael J. Sorich,
- Kim Moretti,
- Lisa M. Butler,
- John J. O’Leary,
- Douglas A. Brooks
Affiliations
- Jessica M. Logan
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Ashley M. Hopkins
- College of Medicine and Public Health, Flinders University, Flinders Drive, Bedford Park, Adelaide, SA 5042, Australia
- Carmela Martini
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Alexandra Sorvina
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Prerna Tewari
- Department of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland
- Sarita Prabhakaran
- Department of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia
- Chelsea Huzzell
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Ian R. D. Johnson
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Shane M. Hickey
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Ben S.-Y. Ung
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Joanna Lazniewska
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Robert D. Brooks
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Courtney R. Moore
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Maria C. Caruso
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Litsa Karageorgos
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Cara M. Martin
- Department of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland
- Sharon O’Toole
- Department of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland
- Laura Bogue Edgerton
- Department of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland
- Mark P. Ward
- Department of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland
- Mark Bates
- Department of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland
- Stavros Selemidis
- School of Health and Biomedical Sciences, STEM College, RMIT University, Bundoora, Melbourne, VIC 3001, Australia
- Adrian Esterman
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- Sheena Heffernan
- Department of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland
- Helen Keegan
- Department of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland
- Sarah Ní Mhaolcatha
- Department of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland
- Roisin O’Connor
- Department of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland
- Victoria Malone
- Department of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland
- Marguerite Carter
- Department of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland
- Katie Ryan
- Department of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland
- Andres Clarke
- Department of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland
- Nathan Brady
- Department of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland
- Sonja Klebe
- Department of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia
- Hemamali Samaratunga
- Aquesta Uropathology, The University of Queensland, Brisbane, QLD 4072, Australia
- Brett Delahunt
- Malaghan Institute of Medical Research, Wellington 6012, New Zealand
- Michael J. Sorich
- College of Medicine and Public Health, Flinders University, Flinders Drive, Bedford Park, Adelaide, SA 5042, Australia
- Kim Moretti
- Discipline of Surgery, University of Adelaide, Adelaide, SA 5371, Australia
- Lisa M. Butler
- South Australian ImmunoGENomics Cancer Institute and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA 5005, Australia
- John J. O’Leary
- Department of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland
- Douglas A. Brooks
- Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia
- DOI
- https://doi.org/10.3390/cancers15123215
- Journal volume & issue
-
Vol. 15,
no. 12
p. 3215
Abstract
Gleason scoring is used within a five-tier risk stratification system to guide therapeutic decisions for patients with prostate cancer. This study aimed to compare the predictive performance of routine H&E or biomarker-assisted ISUP (International Society of Urological Pathology) grade grouping for assessing the risk of biochemical recurrence (BCR) and clinical recurrence (CR) in patients with prostate cancer. This retrospective study was an assessment of 114 men with prostate cancer who provided radical prostatectomy samples to the Australian Prostate Cancer Bioresource between 2006 and 2014. The prediction of CR was the primary outcome (median time to CR 79.8 months), and BCR was assessed as a secondary outcome (median time to BCR 41.7 months). The associations of (1) H&E ISUP grade groups and (2) modified ISUP grade groups informed by the Appl1, Sortilin and Syndecan-1 immunohistochemistry (IHC) labelling were modelled with BCR and CR using Cox proportional hazard approaches. IHC-assisted grading was more predictive than H&E for BCR (C-statistic 0.63 vs. 0.59) and CR (C-statistic 0.71 vs. 0.66). On adjusted analysis, IHC-assisted ISUP grading was independently associated with both outcome measures. IHC-assisted ISUP grading using the biomarker panel was an independent predictor of individual BCR and CR. Prospective studies are needed to further validate this biomarker technology and to define BCR and CR associations in real-world cohorts.
Keywords
