Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy

Dahlene N. Fusco; Dahlene N. Fusco; Lilia Ganova-Raeva; Yury Khudyakov; Lili Punkova; Aisha Mohamed; Scarlett Se Yun Cheon; Prapti Koirala; Karin L. Andersson; Gonzague Jourdain; Gonzague Jourdain; Gonzague Jourdain; Camille Sureau; Raymond T. Chung; Georg Lauer

doi:10.3389/fmed.2018.00097

Frontiers in Medicine (Apr 2018)

Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy

Dahlene N. Fusco,
Dahlene N. Fusco,
Lilia Ganova-Raeva,
Yury Khudyakov,
Lili Punkova,
Aisha Mohamed,
Scarlett Se Yun Cheon,
Prapti Koirala,
Karin L. Andersson,
Gonzague Jourdain,
Gonzague Jourdain,
Gonzague Jourdain,
Camille Sureau,
Raymond T. Chung,
Georg Lauer

Affiliations

Dahlene N. Fusco: Medicine/General Internal Medicine and Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
Dahlene N. Fusco: Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, United States
Lilia Ganova-Raeva: Molecular Epidemiology and Bioinformatics Team, DVH/NCHHSTP/CDC, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States
Yury Khudyakov: Molecular Epidemiology and Bioinformatics Team, DVH/NCHHSTP/CDC, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States
Lili Punkova: Molecular Epidemiology and Bioinformatics Team, DVH/NCHHSTP/CDC, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States
Aisha Mohamed: Cooper Medical School of Rowan University, Camden, NJ, United States
Scarlett Se Yun Cheon: Wellesley College, Wellesley, MA, United States
Prapti Koirala: Wellesley College, Wellesley, MA, United States
Karin L. Andersson: Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
Gonzague Jourdain: Institut de recherche pour le développement(IRD), Marseille, France
Gonzague Jourdain: Chiang Mai University, Chiang Mai, Thailand
Gonzague Jourdain: Harvard School of Public Health, Boston, MA, United States
Camille Sureau: 0Institut National de la Tranfusion Sanguine INSER U1134, Paris, France
Raymond T. Chung: Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
Georg Lauer: Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

DOI: https://doi.org/10.3389/fmed.2018.00097
Journal volume & issue: Vol. 5

Abstract

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A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multiple mutations including vaccine escape mutation and mutations predicted to enhance fitness. This case represents exacerbation of an HBV vaccine escape mutant during a direct-acting antiviral therapy.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

About the journal

Abstract

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