Nature Communications (Jan 2021)
Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans
- Laura K. Case,
- Jaquette Liljencrantz,
- Nicholas Madian,
- Aaron Necaise,
- Justin Tubbs,
- Micaela McCall,
- Megan L. Bradson,
- Marcin Szczot,
- Mark H. Pitcher,
- Nima Ghitani,
- Eleni Frangos,
- Jonathan Cole,
- Diana Bharucha-Goebel,
- Dimah Saade,
- Tracy Ogata,
- Sandra Donkervoort,
- A. Reghan Foley,
- Carsten G. Bönnemann,
- Håkan Olausson,
- M. Catherine Bushnell,
- Alexander T. Chesler
Affiliations
- Laura K. Case
- National Center for Complementary and Integrative Health, NIH
- Jaquette Liljencrantz
- National Center for Complementary and Integrative Health, NIH
- Nicholas Madian
- National Center for Complementary and Integrative Health, NIH
- Aaron Necaise
- National Center for Complementary and Integrative Health, NIH
- Justin Tubbs
- National Center for Complementary and Integrative Health, NIH
- Micaela McCall
- National Center for Complementary and Integrative Health, NIH
- Megan L. Bradson
- National Center for Complementary and Integrative Health, NIH
- Marcin Szczot
- National Center for Complementary and Integrative Health, NIH
- Mark H. Pitcher
- National Center for Complementary and Integrative Health, NIH
- Nima Ghitani
- National Center for Complementary and Integrative Health, NIH
- Eleni Frangos
- National Center for Complementary and Integrative Health, NIH
- Jonathan Cole
- Centre of Postgraduate Medical Research and Education, Bournemouth University
- Diana Bharucha-Goebel
- National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Dimah Saade
- National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Tracy Ogata
- National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Sandra Donkervoort
- National Institute of Neurological Disorders and Stroke, National Institutes of Health
- A. Reghan Foley
- National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Carsten G. Bönnemann
- National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Håkan Olausson
- Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine, Linköping University
- M. Catherine Bushnell
- National Center for Complementary and Integrative Health, NIH
- Alexander T. Chesler
- National Center for Complementary and Integrative Health, NIH
- DOI
- https://doi.org/10.1038/s41467-021-20939-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
The mechanisms underlying deep pressure sensing are not fully understood. Here the authors demonstrate that while two individuals lacking Aβ fibers demonstrate impaired deep pressure sensing, seven individuals with PIEZO2 loss of function mutations display normal deep pressure responses.
