Nature Communications (Sep 2021)

Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles

  • Ann-Kathrin Volz,
  • Alina Frei,
  • Viola Kretschmer,
  • António M. de Jesus Domingues,
  • Rene F. Ketting,
  • Marius Ueffing,
  • Karsten Boldt,
  • Eva-Maria Krämer-Albers,
  • Helen L. May-Simera

DOI
https://doi.org/10.1038/s41467-021-25929-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Extracellular vesicles (EV) are known to be released from the primary cilium, but the role ciliary proteins play in EV biogenesis remains unexplored. Here, the authors demonstrate increased secretion of small EVs with altered cargo composition from cells with known ciliarelated mutations. Wnt related molecules made up a majority of altered cargo