Generation of a human iPSC line CIBi009-A from a patient with familial hypercholesterolemia carrying variants of LDLR c.T1241G and APOB c.G1618T

Wenkun Ge; Yizhe Song; Meng Chu; Yuqing Liu; Bo Yang; Kejian Wang; Baorong Yu; Chunyang Song; Yong Wang; Jiayin Yang

Stem Cell Research (May 2021)

Generation of a human iPSC line CIBi009-A from a patient with familial hypercholesterolemia carrying variants of LDLR c.T1241G and APOB c.G1618T

Wenkun Ge,
Yizhe Song,
Meng Chu,
Yuqing Liu,
Bo Yang,
Kejian Wang,
Baorong Yu,
Chunyang Song,
Yong Wang,
Jiayin Yang

Affiliations

Wenkun Ge: Department of Cardiology, The First People’s Hospital of Shangqiu, Shangqiu 476100, China
Yizhe Song: Department of Histology and Embryology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China
Meng Chu: Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China
Yuqing Liu: Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China
Bo Yang: Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China
Kejian Wang: The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences), Jinan 250031, China
Baorong Yu: Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China
Chunyang Song: Department of Cardiology, Shangqiu Municipal Hospital, Shangqiu 476100, China
Yong Wang: Department of Cardiology, The First People’s Hospital of Shangqiu, Shangqiu 476100, China
Jiayin Yang: Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China; Cell Inspire Therapeutics Co., Ltd., Shenzhen 518101, China; Corresponding author at: Room 115, Incubation Block A, Taohuayuan Science and Technology Innovation Park, Bao’an District, Shenzhen 518101, China.

Journal volume & issue: Vol. 53
p. 102347

Abstract

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Patients with familial hypercholesterolemia (FH) are susceptible to premature coronary artery disease. We generated a human iPSC line CIBi009-A from a patient with FH who carried variants of LDLR c.T1241G and APOB c.G1618T. This line will be a valuable resource for investigating novel therapeutic approaches to FH.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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