Using electronic health data to explore effectiveness of ICU EEG and anti‐seizure treatment

Abstract

Abstract Objectives The purpose of this study was to examine critical care continuous electroencephalography (cEEG) utilization and downstream anti‐seizure treatment patterns, their association with outcomes, and generate hypotheses for larger comparative effectiveness studies of cEEG‐guided interventions. Methods Single‐center retrospective study of critically ill patients (n = 14,523, age ≥18 years). Exposure defined as ≥24 h of cEEG and subsequent anti‐seizure medication (ASM) escalation, with or without concomitant anesthetic. Exposure window was the first 7 days of admission. Primary outcome was in‐hospital mortality. Multivariable analysis was performed using penalized logistic regression. Results One thousand and seventy‐three patients underwent ≥24 h of cEEG within 7 days of admission. After adjusting for disease severity, ≥24 h of cEEG followed by ASM escalation in patients not on anesthetics (n = 239) was associated with lower in‐hospital mortality (OR 0.76 [0.53–1.07]), though the finding did not reach significance. ASM escalation with concomitant anesthetic use (n = 484) showed higher odds for mortality (OR 1.41 [1.03–1.94]). In the seizures/status epilepticus subgroup, post cEEG ASM escalation without anesthetics showed lower odds for mortality (OR 0.43 [0.23–0.74]). Within the same subgroup, ASM escalation with concomitant anesthetic use showed higher odds for mortality (OR 1.34 [0.92–1.91]) though not significant. Interpretation Based on our findings we propose the following hypotheses for larger comparative effectiveness studies investigating the direct causal effect of cEEG‐guided treatment on outcomes: (1) cEEG‐guided ASM escalation may improve outcomes in critically ill patients with seizures; (2) cEEG‐guided treatment with combination of ASMs and anesthetics may not improve outcomes in all critically ill patients.