A new labdane-type diterpenoid from leaves of Vitex rotundifolia

Yusuke Hanaki; Rintaro Abe; Yasunori Sugiyama; Yasumasa Hara; Ryo C. Yanagita

Results in Chemistry (Jan 2024)

A new labdane-type diterpenoid from leaves of Vitex rotundifolia

Yusuke Hanaki,
Rintaro Abe,
Yasunori Sugiyama,
Yasumasa Hara,
Ryo C. Yanagita

Affiliations

Yusuke Hanaki: Corresponding author at: Faculty of Agriculture, Kagawa University, Ikenobe, Miki-cho, Kita, Kagawa 761-0795, Japan.; Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, 2393, Ikenobe, Miki, Kita, Kagawa 761-0795, Japan
Rintaro Abe: Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, 2393, Ikenobe, Miki, Kita, Kagawa 761-0795, Japan
Yasunori Sugiyama: Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, 2393, Ikenobe, Miki, Kita, Kagawa 761-0795, Japan
Yasumasa Hara: Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, 2393, Ikenobe, Miki, Kita, Kagawa 761-0795, Japan
Ryo C. Yanagita: Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, 2393, Ikenobe, Miki, Kita, Kagawa 761-0795, Japan

Journal volume & issue: Vol. 7
p. 101512

Abstract

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Vitex rotundifolia is a folk medicinal plant that has been used to treat various diseases. We have previously found that the extract of its leaves shows cytotoxic and epithelial mesenchymal transition inhibitory effect in HHUA endometrial cells. In this study, a new labdane-type diterpenoid 1 was isolated and its structure was elucidated by NMR and CD spectroscopic analysis followed by density functional theory calculations. Compound 1 showed cytotoxicity toward HHUA cells with an IC50 value of 6.4 μM, but did not inhibit phorbol ester-induced epithelial mesenchymal transition nor lipopolysaccharide-stimulated nitric oxide production.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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