Nature Communications (Sep 2021)
The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
- Chen Shen,
- Anmada Nayak,
- Leif R. Neitzel,
- Amber A. Adams,
- Maya Silver-Isenstadt,
- Leah M. Sawyer,
- Hassina Benchabane,
- Huilan Wang,
- Nawat Bunnag,
- Bin Li,
- Daniel T. Wynn,
- Fan Yang,
- Marta Garcia-Contreras,
- Charles H. Williams,
- Sivanesan Dakshanamurthy,
- Charles C. Hong,
- Nagi G. Ayad,
- Anthony J. Capobianco,
- Yashi Ahmed,
- Ethan Lee,
- David J. Robbins
Affiliations
- Chen Shen
- Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami
- Anmada Nayak
- Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami
- Leif R. Neitzel
- Department of Medicine, University of Maryland
- Amber A. Adams
- Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College
- Maya Silver-Isenstadt
- Department of Medicine, University of Maryland
- Leah M. Sawyer
- Department of Cell and Developmental Biology, Vanderbilt University
- Hassina Benchabane
- Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College
- Huilan Wang
- Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami
- Nawat Bunnag
- Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College
- Bin Li
- Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami
- Daniel T. Wynn
- Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami
- Fan Yang
- Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami
- Marta Garcia-Contreras
- Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami
- Charles H. Williams
- Department of Medicine, University of Maryland
- Sivanesan Dakshanamurthy
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University
- Charles C. Hong
- Department of Medicine, University of Maryland
- Nagi G. Ayad
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University
- Anthony J. Capobianco
- Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami
- Yashi Ahmed
- Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College
- Ethan Lee
- Department of Cell and Developmental Biology, Vanderbilt University
- David J. Robbins
- Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami
- DOI
- https://doi.org/10.1038/s41467-021-25634-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Cereblon (CRBN) is an E3 ubiquitin ligase substrate receptor that is involved in cancer cell death, although its regulation is poorly understood. Here, the authors show that Wnt ligand increases CRBN-dependent protein degradation and demonstrate CRBN’s importance in physiological Wnt signaling.
