Dataset on gene expression in the elderly after Mindfulness Awareness Practice or Health Education Program
Hwee-Woon Lim,
Woei-Yuh Saw,
Lei Feng,
Yuan-Kun Lee,
Ratha Mahendran,
Irwin Kee-Mun Cheah,
Iris Rawtaer,
Alan Prem Kumar,
Ee-Heok Kua,
Rathi Mahendran,
Ene-Choo Tan
Affiliations
Hwee-Woon Lim
KK Research Laboratory, KK Women's and Children's Hospital, Singapore
Woei-Yuh Saw
Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Life Sciences Institute, National University of Singapore, Singapore
Lei Feng
Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Yuan-Kun Lee
Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Hospital, Singapore
Ratha Mahendran
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Irwin Kee-Mun Cheah
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Iris Rawtaer
Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Alan Prem Kumar
Medical Science Cluster, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Ee-Heok Kua
Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Rathi Mahendran
Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Duke-NUS Medical School, Singapore
Ene-Choo Tan
KK Research Laboratory, KK Women's and Children's Hospital, Singapore; SingHealth Duke-NUS Paediatrics Academic Clinical Program, Singapore; Corresponding author at: KK Research Centre, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
It has been reported that relaxation techniques can improve physical health and cognitive function. A number of studies involving different types of relaxation practices showed changes in expression of genes. We investigated the gene expression pattern of a cohort of elderly subjects of Asian descent after weekly (for the first three months) and monthly (for the subsequent six months) intervention. Sixty consenting elderly subjects (aged 60–90 years) with mild cognitive impairment were assigned to either the Mindfulness Awareness Practice (MAP) or Health Education Program (HEP) group in a randomized controlled trial to assess the effectiveness of the programs in preventing further cognitive decline and evaluate the influence on neurological, cellular and biochemical factors. Blood samples were collected before the start of intervention and after nine months for gene expression profiling using Affymetrix Human Genome U133 Plus 2.0 arrays. The dataset is publicly available for further analyses. Keywords: Elderly, Gene expression, Mild cognitive impairment, Mindfulness Awareness Practice, Health education program
