Nature Communications (Mar 2023)

Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity

  • Wan-Ru Zhuang,
  • Yunfeng Wang,
  • Weidong Nie,
  • Yao Lei,
  • Chao Liang,
  • Jiaqi He,
  • Liping Zuo,
  • Li-Li Huang,
  • Hai-Yan Xie

DOI
https://doi.org/10.1038/s41467-023-37369-0
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 15

Abstract

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Efferocytosis inhibition leads to the release of immunogenic contents into the tumor microenvironment. Here the authors developed a nanosystem that inhibits MerTK-mediated efferocytosis and captures tumor-associated agents to enhance antitumour immunity.