Frontiers in Chemistry (Sep 2022)
Curcumanes E and F, two rare sesquiterpenoids with a dicyclo[3.3.1]nonane moiety, from Curcuma longa and their vasorelaxant activities
- Juan Liu,
- Juan Liu,
- Juan Liu,
- Ming-Ming Qiao,
- Ming-Ming Qiao,
- Ming-Ming Qiao,
- Cheng Peng,
- Cheng Peng,
- Hong-Zhen Shu,
- Hong-Zhen Shu,
- Hong-Zhen Shu,
- Chun-Wang Meng,
- Chun-Wang Meng,
- Chun-Wang Meng,
- Fei Liu,
- Fei Liu,
- Fei Liu,
- Liang Xiong,
- Liang Xiong,
- Liang Xiong
Affiliations
- Juan Liu
- State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Juan Liu
- School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Juan Liu
- Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Ming-Ming Qiao
- State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Ming-Ming Qiao
- School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Ming-Ming Qiao
- Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Cheng Peng
- State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Cheng Peng
- School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Hong-Zhen Shu
- State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Hong-Zhen Shu
- School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Hong-Zhen Shu
- Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Chun-Wang Meng
- State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Chun-Wang Meng
- School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Chun-Wang Meng
- Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Fei Liu
- State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Fei Liu
- School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Fei Liu
- Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Liang Xiong
- State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Liang Xiong
- School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Liang Xiong
- Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- DOI
- https://doi.org/10.3389/fchem.2022.995950
- Journal volume & issue
-
Vol. 10
Abstract
Two new sesquiterpenoids, curcumanes E (1) and F (2), were isolated from the rhizome of Curcuma longa, and their structures and absolute configurations were examined using extensive spectroscopic analyses and ECD calculations. Interestingly, compounds 1 and 2 are diastereoisomers possessing a rare sesquiterpenoid skeleton that has been reported only once before. Both curcumanes E and F exhibit significant vasorelaxant effects against KCl-induced contraction of rat aortic rings, with EC50 values of 5.10 ± 0.79 and 5.58 ± 1.77 μM, respectively. These findings enrich the data concerning this rare type of sesquiterpenoids and further indicate that these rare sesquiterpenoids can effectively reduce blood pressure.
Keywords
