PECULIARITIES OF PURINE METABOLISM AND LIPID PEROXIDATION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Abstract

Aim. To study purine metabolism and lipid peroxidation in patients with acute myocardial infarction with ST segment elevation (STEMI) in dependence on severity of acute heart failure (AHF). To evaluate effects of thrombolytic therapy on purine metabolism and lipid peroxidation.Material and methods. 91 patients (age 60,8±1,2 y.o.) with STEMI and AHF (Killip 1-3) was included into the study. Patients were randomized into 3 groups in dependence of AHF severity. Markers of purine metabolism (activity of 5’- nucleotidase, xantineoxidase and uric acid level) and lipid peroxidation (superoxide dismutase and catalase activity, superoxide-anione radical level) were evaluated.Results. Purine metabolism activity increases, antioxidant and prooxidant balance disturbs at the condition of energy deficiency. AHF progression leads to increase in xanthine oxidize activity, urinary acid level and lungs edematization. Thrombolytic therapy increases antioxidant activity (response on reperfusion), but does not lead to purine metabolism stabilization.Conclusion. Thus, severity of heart failure in patients with STEMI correlates with disorders of purine and lipid metabolism. Thrombolytic therapy leads to rising in antioxidant protection, but does not lead to stabilisation of purine metabolism.

Keywords

• myocardial infarction
• heart failure
• thrombolysis